TH and Parkinson disease: This interaction was closely reflected in the findings of this study, as it was predicted that another miRNA, miR-6754-5p, was sponged by circVCAN to up-regulate the expression of MEF2D. Moreover, Yao, Li (2012) [121] proposed the use of bis(3)-cognition to activate MEF2D, which they achieved to ameliorate motor defects by maintaining redox homeostasis and restoring tyrosine hydroxylase signal in the substantia nigra of PD samples.