ARF6 was observed as one of the regulators to recruit PIP5K1γ and elevate the expression of the membrane lipid phosphoinositide PI(4,5)P2, consequently seeding aggregation of ɑ-syn, augmenting mitochondrial IP3-mediated Ca2+ release, and eventually modulating neurotoxicity in PD [93]. The gene discussed is ARF6; the disease is Parkinson disease.