Potentiation of the C3-/late myCAF-like substate upon surgical (PDX) or chemical (PtenPC−/−; Trp53PC−/− PCa model) castration in conjunction with the insensitivity of C3 cell proliferation/migration to AR modulation further implicate the C3/late myCAF substate in CRPC. The gene discussed is AR; the disease is posterior cortical atrophy.