Similarly, the highest-scoring C1 HALLMARK pathway “TNFA_signaling_via_NFKB” and C1 marker genes were abundant in normal prostate tissues but significantly decreased in primary PCa and metastatic castration-resistant PCa (mCRPC; Fig. 2G, Supplemental Fig. S8A). The gene discussed is NFKB1; the disease is posterior cortical atrophy.