Besides the SMC/pericyte cluster c0, expression of the orthologous C3 gene signature in the mouse PCa GEMM atlas was largely restricted to the ECM/collagen-rich CAF clusters c5-c7, which were highly enriched in the aggressive PRN model that develops NEPC [29] with C3 markers also expressed at markedly later timepoints of the myCAF activation trajectory (Fig. 2H-K, Supplemental Fig. S9I-J). The gene discussed is C5; the disease is posterior cortical atrophy.