Indeed, C2 exhibited similarity to several iCAF subsets distinct to those of C1, including Kieffer IL iCAF [17], Nicolas cluster 3 IL1 TNFa iCAF [15], Chen early PCa CAF [18], and PDPN+/SELENOP+/SMAlow CAF-S5 [19, 20] (Fig. 1I-J, Supplemental Fig. S3E). Here, PDPN is linked to posterior cortical atrophy.