Notably, human orthologs to markers defining SPP1+ myCAF/CRPC-CAF (including Spp1, Cald1, Tagln2, Tpm1, Col8a1) that were selectively enriched following ADT treatment of the refractory prostate-specific PtenPC−/−;Trp53PC−/− double knockout PCa model [52], were significantly upregulated in our C3 explant cultures. Here, TPM1 is linked to posterior cortical atrophy.