AR expression was potently reduced by recombinant TGFβ1 and significantly upregulated in C3/myCAF upon pharmacological TGFβR inhibition or YAP1 siRNA-mediated knockdown with a similar trend observed upon pharmacological YAP1 targeting implicating the concerted suppressive action of TGFβ and YAP1 in contributing to stromal AR loss in PCa. The gene discussed is YAP1; the disease is posterior cortical atrophy.