In further support of the relevance of YAP1 signaling in the PCa TME in vivo, YAP1 target genes were abundantly expressed in the intact and castrated LAPC9 stroma and enriched in stromal cells/fibroblasts of aggressive PCa in the PCCAT, PCA and PCa GEMM single cell atlases (Supplemental Fig. S7-9, S13). This evidence concerns the gene YAP1 and posterior cortical atrophy.