A2M and posterior cortical atrophy: Likewise, C2 cultures expressed prostate-associated gene 4 (PAGE4), a highly intrinsically disordered stress-response protein implicated in attenuating PCa cell invasion, epithelial AR activity and canonical Wnt/β-catenin signaling [35–37], and alpha-2-macroglobulin (A2M), which acts as an intra- and extra-cellular chaperone of inflammatory cytokines, including IL1β, and activates the complement cascade [38], an iCAF hallmark pathway that was also upregulated in C2 cultures (Fig. 1G).