In contrast and consistent with the above in vitro findings, AR was expressed at significantly lower levels in ITGA11+/ENG+ myCAF in clinical PCa and was significantly decreased in samples of the SU2C metastatic cohort exhibiting a C3 profile (Fig. 6D-E, Supplemental Fig. S11D-F). The gene discussed is ITGA11; the disease is posterior cortical atrophy.