C3 and posterior cortical atrophy: Whilst general activation and C3 markers were expressed in the intact BM18 model, their expression levels were markedly higher in intact LACP9 xenografts (Fig. 8B, Supplemental Fig. S12A), an observation consistent with the more aggressive phenotype of the LAPC9 model and enrichment of C3 markers in advanced PCa (Fig. 2, Supplemental Fig. S7-9).