SPP1 and posterior cortical atrophy: Moreover, both the intact and castrated LAPC9 stroma exhibited significant upregulation of genes that demarcated the Spp1+ myCAF/CRPC-CAF cluster 5 that was specifically enriched in the aggressive PtenPC−/−; Trp53PC−/− PCa model following ADT (Fig. 8H, Supplemental Fig. S12G) and whose targeted deletion greatly extended lifespan of the double knockout mice [52].