Like SB431542 and VT107 cotreatment, combined silencing of both YAP1 and TGFBR1 were required for robust downregulation of ITGA11 and SMA protein levels and sufficient to significantly attenuate CAF-induced proliferation of directly co-cultured DU145 and PC3 PCa cells (Fig. 10A-D and data not shown). Here, ITGA11 is linked to posterior cortical atrophy.