Moreover, lineage tracing confirmed that SPP1+ myCAF arise from iCAF present in hormone-sensitive PCa [52], whereby the human orthologs of genes that delineated their iCAF (clusters 1 and 2; Svep1, Col14a1, Pcolce2, Scara3 and Pdgfra) were significantly upregulated in our C1 explant cultures (Fig. 1D, Supplemental Table 3). This evidence concerns the gene SVEP1 and posterior cortical atrophy.