Given the contrasting and opposing effects of RKIP and YY1 on cancer cells, we have identified the RKIP-YY1 axis as “YYR”. In this review, we will be presenting the data on the various molecular vents manifested by RKIP and YY1 and our justification for the new dysregulated YYR(RKIP-YY1) axis in cancer. Here, YY1 is linked to cancer.