APP and Alzheimer disease: Among SORL1’s numerous cargo is Amyloid-β and the amyloid precursor protein (APP): APP-binding by retromer-SORL1 accelerates APP-trafficking out of the early endosome, thereby warding off APP-cleavage and the subsequent formation and secretion of Amyloid-β [1], which links impaired SORL1 with hallmark processes of Alzheimer’s disease (AD).