The median AAO APOE-ε4-negative AD cases was 75 years for those wild-type for SORL1 (10%-90% range: 56–89), 69 years for PTV-carriers (10%-90% range: 52–81), and 66 years for HPV carriers (10%-90% range: 48–86) (Fig. 6, Table S8). This evidence concerns the gene SORL1 and Alzheimer disease.