APOE and Alzheimer disease: The median AAO for APOE-ε4 heterozygous AD cases was 70 years for those wild-type for SORL1 (10%-90% range: 55–82), 61 years for PTV-carriers (10%-90% range: 51–74), and 63 years for HPV-carriers (10%-90% range: 54–78).