The median AAO for APOE-ε4/ε4 AD cases was 64 years for those wild-type for SORL1 (10%-90% range: 54–77), 60 years for PTV-carriers (10%-90% range: 53–65), and 58.5 years for HPV-carriers (10%-90% range: 53–69). The gene discussed is APOE; the disease is Alzheimer disease.