FTO and cardiac hypertrophy: To further elucidate the necessity of FTO dependent m6A methylations and its regulatory mechanisms in stress induced cardiac hypertrophy, MeRIP sequencing was performed for the above analysed FTOcKO and Cre Control (Cre C) animals that underwent sham and TAC surgeries (1 week post-surgery), and the corresponding mice sample inputs were subjected to RNA seq to compare the changes of differential expression with differential methylation (Fig. S1C).