For this purpose, the hiPS-CMs were transfected either with Scr siRNAs or with siRNAs of FTO demethylase, and their hypertrophic response were investigated in the presence or absence of the peptide hormone, Endothelin-1 (ET-1), a well-known mediator of cardiac hypertrophy. The gene discussed is EDN1; the disease is cardiac hypertrophy.