APP and Alzheimer disease: The TgF344-AD transgenic rat model overexpresses the human amyloid precursor protein (APP) with the Swedish mutation and PSEN1 with the Δ exon 9 mutation that results in an age-dependent AD pathology, including the accumulation of amyloid plaques, hyperphosphorylated tau, neuronal loss, gliosis, neuroinflammation, and progressive memory impairment.