In a previous work reporting on bone in chronic kidney disease, we found larger OLS-area in those patients with increased parathyroid hormone levels and histomorphometric high turnover [31], suggesting that in situations when high calcium concentrations are required, i.e. high bone formation in the latter case, the osteocyte might release calcium from its surrounding matrix, termed osteocytic osteolysis. The gene discussed is PTH; the disease is chronic kidney disease.