MAPT and Alzheimer disease: Given the frequent co-occurrence of LB, SP and NFT pathologies in LBD, we here aimed to assess their independent association with the mitophagy marker pS65-Ub and analyze how the core α-synuclein pathology interacts with comorbid AD-type pathology (tau or amyloid β) to impact mitophagy alteration using a cohort of 371 autopsy-defined LBD cases.