In line with these observations, we found that in 100% plasma of TYGER study participants (Gibani et al, 2019), the concentration of LYZ increased from 27 μg/ml in non-infected participants to 40 μg/ml at the time of typhoid fever diagnosis due to wild-type S. Typhi (Fig. EV2B). The gene discussed is LYZ; the disease is typhoid fever.