The m5C recognition protein YBX1 recognizes m5C-modified mRNA through the W65 indole ring in its cold shock domain and subsequently recruits ELAV like protein 1 (ELAVL1) to stabilize heparin-binding growth factor mRNA, which ultimately promotes bladder cancer cell proliferation and metastasis (Chen et al, 2019). The gene discussed is HDGF; the disease is urinary bladder cancer.