VHL and nonpapillary renal cell carcinoma: To further refine loci that contained correlated variants, we annotated variants with transcription-factor (TF) binding information, focusing on pathways relevant to ccRCC biology, particularly the hypoxia-inducible factor (HIF) pathways, which is dysregulated in ~80% of ccRCC cases due to VHL loss (Supplementary Data 1)2.