INSR and renal cell carcinoma: Similarly, MPRA data indicates that rs4389139 (r2 = 0.88 to candidate variant, rs11643164, 16q12.1) affects HEATR3 expression, and rs2860183 (r2 = 0.99 to candidate variant, rs11085214, 19p13.2) affects INSR expression in RCC (Supplementary Data 3).