POT1 and nonpapillary renal cell carcinoma: In addition to these two associations, an additional six LTL loci were associated with ccRCC at region-wide significance (i.e. P < 3.45 × 10-4; 0.05/145 LTL loci), including telomere related genes RTEL1 and POT1. To examine whether this apparent genetic pleiotropy was reflected genome-wide, we performed a genetic correlation using LDAK52.