In 480 cases, 93.5% were renamed as squamous cell carcinoma and 4.2% renamed as adenocarcinomas1 and used immunohistochemical markers, counting p40 and TTF-1 types which have been emphasized in recognizing between squamous cell carcinoma and adenocarcinoma, especially in ineffectively separated cases. The gene discussed is TTF1; the disease is squamous cell carcinoma.