CASP8 and neoplasm: Comprehensive biological parameters were measured, including tumor progression (mass and volume), metabolic profile (total cholesterol, triglycerides, HDL-C), liver and kidney function markers (ALT, AST, ALP, creatinine, urea), oxidative stress indicators (GSH, SOD, CAT, MDA), inflammatory cytokines (TNF-alpha, IL-6, VEGF), and gene expression levels (STAT3, caspase 8, P53 via qRT-PCR).