This analysis established a significant correlation between the level of MCL1 and mTORC1 activity in melanoma: MCL1 was almost undetectable in nevi, and its low expression was associated with very low basal mTORC1 signaling activity, whereas elevated MCL1 levels in melanoma samples significantly correlated with the magnitude of activation of mTORC1 as indicated by the phosphorylation of its downstream target S6 protein (Spearman’s rho = 0.67, p = 7.3e-07). The gene discussed is MCL1; the disease is melanoma.