Mechanistically, CX-5461 modulates CD36-ACSL4-mediated glycerophospholipid metabolism in B cells, triggers ferroptosis via the p53-SLC7A11- Arachidonate 12-Lipoxygenase (ALOX12) pathway and lowers IgG and anti-dsDNA antibody levels, thus attenuating lupus pathogenesis. The gene discussed is ALOX12; the disease is systemic lupus erythematosus.