SLC7A11 and hemochromatosis type 1: Macrophage ferroptosis was first described in hemochromatosis, where iron citrate overload can induce ferroptosis in primary mouse hepatocytes and bone marrow-derived macrophages, accompanied by upregulation of Solute Carrier Family 7 member 11(SLC7A11), increased ROS, and increased nuclear Nrf2 [59].