Decreased levels of COL4A1, DEK, GINS1, HPCAL1, KIF4A and RBMX predicted longer survival in esophageal cancer patients (Supplementary Fig. 5A), while overexpression of IGFL1P1, LRRC57A-AS1, SNHG3, ULK3 and ZFYVE19 correlated with longer survival (Supplementary Fig. 5B). This evidence concerns the gene COL4A1 and esophageal cancer.