The myeloid cell SYK-CARD9 signaling axis may also prevent colitis-associated CRC by activating inflammasomes via commensal gut fungi such as Candida. In MSS CRC, fungal components that promote IL-17A activation, such as HKCA, can render tumors more susceptible to PD-1 inhibitors [120]. The gene discussed is SYK; the disease is colorectal carcinoma.