However, studies have reported elevated adiponectin levels in anorexia nervosa patients, which may cause reduced bone mass through inhibition of osteoblast activity and/or promotion of osteoclastogenesis.162 Similarly, increased adiponectin levels following bariatric surgery or dietary weight loss are related to decreased bone mineral density,167 although the exact mechanisms remain to be elucidated. The gene discussed is ADIPOQ; the disease is anorexia nervosa.