USP25 and head and neck squamous cell carcinoma: Furthermore, Kaplan–Meier analysis based on the TCGA data revealed that HNSCC patients with lower USP25 expression had worse clinical outcomes (Fig. 1D), which was reconfirmed by the Kaplan–Meier plotter database (Fig. 1E), suggesting a potential prognostic role of USP25 in HNSCC.