Disruption of PTEN signaling in the brain has been linked to multiple neurodevelopmental and neuropsychiatric disorders, including macrocephaly, autism spectrum disorder, and epilepsy (Zhou and Parada, 2012; Lim and Crino, 2013; Rademacher and Eickholt, 2019; White et al., 2020). The gene discussed is PTEN; the disease is epilepsy.