LMNA and Hutchinson-Gilford progeria syndrome: Thus, the up-regulation of ER stress response pathways in the aortic tissue in HGPS seems to be cell-type-specific and exclusive to progerin-expressing non-endothelial cells, supporting the previous findings in fibroblasts (Vidak et al, 2023) and VSMCs (Hamczyk et al, 2019) from different HGPS models.