After the EBP-Gd-DO3A or EBP-(Gd-DO3A)3 conjugate was injected, the Gd content in the MDA-MB-231 tumor tissues increased with time during the first 2 h and peaked at 17.70 ± 2.10 nM/g tissue or 30.70 ± 1.90 nM/g tissue at 4 h and decreased to 9.95 ± 1.85 nM/g or 19.42 ± 1.76 nM/g tissue at 24 h (Fig. 4E). This evidence concerns the gene EBP and neoplasm.