EPAS1 and tuberculosis: Notably, Module 2 (158 genes) exhibited strong functional concordance with TB cell marker genes (Fig 14), enriching for angiogenesis (GO:0001525, p-value: 1.15×10−4) and positive regulation of RNA polymerase II (GO:0045944, p-value: 1.32×10−3)—processes consistent with known TB markers EPAS1 and HAND1.