Specifically, in cluster 2 with the highest viral load, only three genes including PUM1 (Pumilio homolog; BMSK0008893), PLX-4 (plexin homolog; BMSK0010793), and blistered (bs) (ortholog of serum response factor; BMSK0013093) were significantly up-regulated by BmNPV infection (Fig 2C). This evidence concerns the gene SRF and infection.