MAPK1 and urinary bladder carcinoma: In another instance, Che et al. [11] showed that treatment of bladder cancer (T24 cells) with different concentrations of oridonin could inhibit transient receptor potential cation channel, subfamily M, member 7 (TRPM7) expression by extracellular signal-regulated kinase (ERK), and AKT signaling pathways, promoting apoptosis and inhibiting the proliferation and migration of bladder cancer.