Our intercellular communication analysis identified the significant regulatory relationships and potential mechanisms of intercellular communication between CXCL9 + macrophages and other cell types, particularly between CXCL9 + macrophages and T/NK cells and epithelial cells, to explore the potential regulatory mechanisms by which CXCL9 + macrophages contribute to better prognosis in breast cancer patients. The gene discussed is CXCL9; the disease is breast cancer.