Variants in genes including TNFRSF13B (transmembrane activator calcium modulator cyclophilin ligand interactor; TACI), MSH5 (Mut S homolog 5), TNFSF10 (Tumour Necrosis Factor Related Apoptosis inducing Ligand; TRAIL), TNFSF12 (TNF-like weak inducer of apoptosis; TWEAK) and TNFRSF13C (B cell activating factor receptor; BAFFR) seem to predispose to, or enhance disease severity in CVID [62]. Here, TNFSF10 is linked to common variable immunodeficiency.