Among malignant subtypes, clear cell renal cell carcinoma (ccRCC) showed distinct Vascular Architecture compared with papillary renal cell carcinoma(pRCC), chromophobe renal cell carcinoma(chRCC), and Xp11.2 translocation/TFE3 fusion-associated renal cell carcinoma(tRCC) (P < 0.01). This evidence concerns the gene TFE3 and hereditary clear cell renal cell carcinoma.