Among malignant subtypes, clear cell renal cell carcinoma (ccRCC) showed distinct Vascular Architecture compared with papillary renal cell carcinoma(pRCC), chromophobe renal cell carcinoma(chRCC), and Xp11.2 translocation/TFE3 fusion-associated renal cell carcinoma(tRCC) (P < 0.01). Here, TFE3 is linked to renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.