While there is only limited data on lipid alterations in the neural retina of Pex1-G843D mice, an elaborate MSI-analysis of RPE flat mount preparations revealed significant reductions in phospholipid DHA and plasmalogens levels implying a more widespread dysfunction in peroxisomal pathways as expectable for a peroxisome biogenesis disorder [64]. The gene discussed is PEX1; the disease is Peroxisome biogenesis disorder-Zellweger syndrome spectrum.