In this study, we demonstrated that (1) serum coagulation and complement marker activity or their expression in the kidneys correlate with each other in our human CKD cohort and in the Nephroseq database; (2) the complement and coagulation cascades in the kidneys are upregulated in mouse models of renal fibrosis; and (3) NAM, a NAD+ precursor, is a novel modulator of this cascade, inflammasomes, and NET formation in adenine‐induced nephropathy. The gene discussed is STAC3; the disease is chronic kidney disease.