An interaction model (Model 3) incorporating an ALDH2*2 × heavy drinking term revealed a borderline significant negative interaction effect (β = −4.81 years, 95% CI: −9.96 to 0.33, p = 0.066), suggesting that heavy drinking might exacerbate the risk of ischemic stroke conferred by the *2 allele, leading to an earlier stroke onset. Here, ALDH2 is linked to ischemic stroke.