Results derived from different reviews have demonstrated that acupuncture, by influencing both specific and nonspecific neurological signaling pathways, alongside the regulation of neuromodulators including cortisol, prolactin, epinephrine, beta endorphin, enkephalins, and stress‐related hormones (e.g., adrenocorticotropic hormone), can mitigate depression, anxiety, and stress [50, 61, 95, 100]. The gene discussed is POMC; the disease is major depressive disorder.