Thus, time-separated stimulation of MYC and NF-κB by EBNA2 and LMP1 factors, respectively, allows EBV to avoid the dangerous activation of two mutually exclusive growth-stimulating signaling pathways for non-transformed cells, thereby achieving both cell survival and proliferation at the early stages of EBV infection, as well as its survival within the germinal center. This evidence concerns the gene MYC and Epstein-Barr virus infection.