Recent studies have also observed deficits in striatal circuits in adult Fmr1 knockout (KO) mice, suggesting a potential role for the striatum in the motor and behavioral symptoms of FXS (Longo et al., 2023; Mercaldo et al., 2023; Huebschman et al., 2022; Neuhofer et al., 2018; Neuhofer et al., 2015; Jung et al., 2012; Huebschman et al., 2020). This evidence concerns the gene FMR1 and fragile X syndrome.