AQP4 and central nervous system cancer: High AQP4 expression in glioma tissues has been associated with a higher prevalence of M2-like TAMs, linking AQP4 to an immunosuppressive tumor niche (Pisani et al., 2021; Lan et al., 2022; Wang et al., 2023; Seifert et al., 2015; Simone et al., 2022; Du et al., 2020).