DHTKD1 and urinary bladder neoplasm: For example, Hu et al. 26 found that intravesical instillation of AxdAdB-3, a lysogenic adenovirus with an E1B-55KD deletion and mutated E1A, significantly slowed bladder tumor growth in an orthotopic model.26 Lichtenegger et al. 27 demonstrated that intratumoral delivery of XVir-N-31, a YB-1-selective adenovirus, significantly inhibited tumor progression and induced a higher level of immunogenic cell death in bladder tumor cells compared to wild-type adenovirus.