Research by Kelly and Kim has indicated that the overexpression of SELENOS can decrease the activity of the glucose‐regulated protein 78 (GRP78) promoter (a marker protein for ER stress) in HepG2 hepatocellular carcinoma cells and also reduce the expression of GRP78 protein induced by thapsigargin (TC) in HEK293T human embryonic kidney cells (Kelly et al. 2009; Kim and Kim 2013). The gene discussed is HSPA5; the disease is hepatocellular carcinoma.