Notably, existing reports have indicated that CBS is upregulated in androgen‐dependent prostate cancer, colon cancer, and ovarian cancer cells (Bhattacharyya et al. 2013; Szabo et al. 2013), In HCC (hepatocellular carcinoma), prostate cancer, and glioma cell lines, the endogenous hydrogen sulfide (H2S) generated by CSE participates in the survival and proliferation of these malignant cell lines (Youness et al. 2021). This evidence concerns the gene CBS and hepatocellular carcinoma.