In a streptozotocin (STZ)‐induced DKD rat model, Ast‐Por‐Rhe supplementation, as a functional food intervention, significantly mitigated renal metabolic dysfunction, evidenced by enhanced IRS1/PI3K/Akt activity, reduced lipid peroxidation, and improved renal fibrosis. The gene discussed is AKT1; the disease is renal fibrosis.