Our survey of MAPK phosphorylation status revealed that JNK, ERK, and p38-MAPK were highly phosphorylated in both OSCC cell lines as treated with 40 and 80 μM IGG (Figures 5A-D), indicating a promotive effect of IGG on MAPKs activation in oral cancer. The gene discussed is MAPK8; the disease is lip and oral cavity carcinoma.