Lipid metabolic adaptation in GBM mediated by CEBPD, BMP7, FOXO1, and LPL overexpression. The upregulation of HIF-1α and adipogenesis-related genes in 3D spheroids supports the hypothesis that GBM cells may activate adipogenic pathways to promote growth, survival, and therapy resistance. The gene discussed is HIF1A; the disease is glioblastoma.