Emerging evidence suggests that cancer cells can co-opt adipogenic transcription factors, such as peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT/enhancer-binding protein alpha (C/EBPα), to facilitate metabolic adaptation within the nutrient-deprived, stress-inducing tumor microenvironment (TME) 17, 18. The gene discussed is PPARG; the disease is neoplasm.