Besides distinctive modulation of numerous cancer hallmarks in cancers of the rectum and colon, these interrupted carcinogenic signaling events collectively induced a key transcriptional activator of NEAT1, hypoxia-inducible factor 2α (HIF-2α) 35, resulting in the discrepancies of local NEAT1 expression within CRC tumor compartments. The gene discussed is EPAS1; the disease is neoplasm.