PTPRG and early-onset autosomal dominant Alzheimer disease: Although deletion of PTPRG does not impair nervous system development, dysregulation of PTPRG and/or PTPRG variants has been associated with multiple neurological disorders, including neuroinflammation, schizophrenia, and Alzheimer’s disease, implying that PTPRG may participate in the regulation of neuronal activities (Lamprianou et al., 2006; Lorenzetto et al., 2014; Boni et al., 2022; Cressant et al., 2017).