MAPT and Alzheimer disease: Second, structural biomarkers and core AD pathologies engage in a complex spatiotemporal dialogue: GM atrophy patterns frequently mirror the topographical spread of tau pathology as captured by Braak staging (Heinzinger et al., 2023), whereas WM injury appears to arise from a confluence of Aβ deposition, vascular compromise, and tau-driven axonal degeneration (Morrison et al., 2023).