The identification of eight TFs—including MAX, ZBTB7A, BRD9, RXRA, MBD4, ARID2, FLI1, and TRIM24—as regulators of MLEC, TMEM59, GFAP, and FOS expands our understanding of the gene regulatory networks that orchestrate glycosylation and neuroinflammatory responses in AD. The gene discussed is TMEM59; the disease is Alzheimer disease.