The identification of eight TFs—including MAX, ZBTB7A, BRD9, RXRA, MBD4, ARID2, FLI1, and TRIM24—as regulators of MLEC, TMEM59, GFAP, and FOS expands our understanding of the gene regulatory networks that orchestrate glycosylation and neuroinflammatory responses in AD. This evidence concerns the gene ARID2 and Alzheimer disease.