While the previous ESC-ESVS guidelines (published in 2017) [4] for PAD were lacking specific mention regarding the roles of prognostic biomarkers in this disease, the latest guideline stated that increased levels of CRP, D-dimer, fibrinogen, and NT-proBNP were associated with mortality and MACE in PAD patients [25]. This evidence concerns the gene NPPB and peripheral arterial disease.