These SNPs classify mineralocorticoid receptor (MR) haplotype. The authors note variability in the depressogenic effects or depression-protection for OC users. They cite animal studies showing estrogen and progesterone affect MR binding and that MR is tied to mood and stress response and hypothesize that synthetic hormones effects on mood might be moderated by different MR haplotypes. Here, NR3C2 is linked to depressive disorder.