For instance, PSG1 (Pregnancy specific beta-1-glycoprotein 1), an immunoglobulin highly expressed in several kinds of cancers, involves in the regulation of placental growth factor (PGF), TGF-β-mediated vascular endothelial growth factor (VEGF) and the activation and proliferation of T-cell (14). The gene discussed is TGFB1; the disease is cancer.