MAP2K7 and neoplasm: Unsurprisingly, the decline of tumor cell miR-331-3p expression promoted the MAP2K7/p-ERK/p-p38MAPK signaling cascade, while the superfluous miR-331-3p downregulated the protein level and activity of this signaling axis factors; however, simultaneously inhibiting or overexpressing miR-331-3p and circ_0060927 reversed the changes in the activity of the MAP2K7/p-ERK/p-p38MAPK signaling axis induced by manipulating miR-331-3p (Figure 3G).