In addition, studies in bladder cancer demonstrate that specific circRNAs can scaffold the WTAP/METTL3/METTL14 complex to remodel m6A on target mRNAs and thereby modulate chemosensitivity, highlighting the potential bidirectional interplay between circRNAs and the m6A machinery in cancer (57). The gene discussed is WTAP; the disease is urinary bladder carcinoma.