The frequency of NTRK-associated gene fusion is approximately 1% of all solid tumors,16,17 and in STS, less than 1%.16, –18 However, in rare cancers, the frequency of NTRK-associated gene fusions is up to 90%.15,16 For instance, in infantile fibrosarcoma, the ETV6::NTRK3 gene fusion was reported in more than 90% of cases.15 In addition, LMNA::NTRK1 and STRN::NTRK2 gene fusions not associated with the subtype were found in some sarcoma cases.19, , , –23. This evidence concerns the gene NTRK2 and sarcoma.