Potential mechanisms discussed in current literature that may underlie the link between IL-6 levels and cognitive deficits include the neurodegenerative effects of elevated IL-6 levels (Harrell et al., 2021; Morales et al., 2010) and its association with blood-brain barrier dysfunction and subsequent cognitive impairment (Mei et al., 2021). Here, IL6 is linked to Cognitive impairment.